Label-free cell sorting based on intrinsic cell properties

Selective enrichment of cell populations based on intrinsic mechanical and morphological properties — without labels, antibodies, or prior sample preparation.

Developed by ZELLMECHANIK DRESDEN for academic research.

Why label-free sorting?

  • Preserves native cell state

  • No reagents, no bias

  • Compatible with downstream assays

Especially relevant for fragile, primary, or heterogeneous cell populations.

How it works

  1. Measure intrinsic properties (size, deformation, morphology)

  2. Decide in real time

  3. Sort mechanically, label-free

Based on real-time deformability cytometry (RT-DC).

Representative results

Scatter plot of cell deformation versus cell area showing label-free cell sorting. Before sorting, two overlapping populations are visible; after size-based sorting, a narrow, enriched population remains.

Enriched lymphocytes from a leucocyte sample

Representative data showing label-free size-based enrichment of a cell population. The target fraction increased from 2174 / 4218 cells (51.6%) before sorting to 558 / 564 cells (98.9%) after sorting. Reduced event count reflects selective gating.

Talk to us about your applications.

About this technology

It is

  • Label-free enrichment

  • Property-based sorting

  • Research-focused technology

It is not

  • A replacement for high-throughput FACS

  • Antibody-based phenotyping

  • Clinical-grade sorting

Product link

Label-free sorting is available as a module integrated into ZELLMECHANIK DRESDEN systems.

View the SortingModule
©2026  ZELLMECHANIK DRESDEN
⇑